Carna BiosciencesCarna Biosciences, Inc.4572東証グロース医薬品FY ending Dec 2025, consolidated, J-GAAP

Carna Biosciences revenue and profit

It lost about ¥358 for every ¥100 of sales at the operating level. Revenue changed -9.0% from the prior year.

Five-year trend

Revenue¥579.1M
FY ending Dec 2021: ¥2.02B¥2.02BFY ending Dec 2022: ¥1.39B¥1.39BFY ending Dec 2023: ¥1.63B¥1.63BFY ending Dec 2024: ¥636.2M¥636.2MFY ending Dec 2025: ¥579.1M¥579.1MFY21FY22FY23FY24FY25
Operating income-¥2.07B
FY ending Dec 2021: -¥531.1M-¥531.1MFY ending Dec 2022: -¥1.27B-¥1.27BFY ending Dec 2023: -¥1.12B-¥1.12BFY ending Dec 2024: -¥2.08B-¥2.08BFY ending Dec 2025: -¥2.07B-¥2.07BFY21FY22FY23FY24FY25
Operating margin-358.3%
FY ending Dec 2021: -26.3%-26.3%FY ending Dec 2022: -91.6%-91.6%FY ending Dec 2023: -68.7%-68.7%FY ending Dec 2024: -326.3%-326.3%FY ending Dec 2025: -358.3%-358.3%FY21FY22FY23FY24FY25

What drives ROE

Net margin × asset turnover = ROA; ROA × financial leverage = ROE

ROA-108.5%
2021: -9.8%-9.8%2022: -27.8%-27.8%2023: -26.8%-26.8%2024: -61.2%-61.2%2025: -108.5%-108.5%2122232425
PeriodNet marginAsset turnoverROAFinancial leverageROE
2021——×-9.8%—×—
2022——×-27.8%—×—
2023——×-26.8%—×—
2024——×-61.2%—×—
2025——×-108.5%—×—

Financial leverage can raise ROE; a higher value alone does not describe a company's overall condition.

Asset intensity and goodwill

Annual trends in tangible-asset ratios and goodwill balance.

PPE ÷ revenue—
2020: 4.7%4.7%2021: 2.6%2.6%2022: 7.2%7.2%2023: 6.5%6.5%202122232425
PPE ÷ total assets—
2020: 1.1%1.1%2021: 0.9%0.9%2022: 2.3%2.3%2023: 2.4%2.4%202122232425

Ratios are derived from reported values. Goodwill is shown only when separately reported; it is not inferred from combined intangible assets. Definition

Investment and working-capital efficiency

Track R&D investment and how long operating capital remains tied up before sales turn into cash.

R&D spending¥1.85B
2020: ¥1.47B¥1.47B2021: ¥1.84B¥1.84B2022: ¥1.88B¥1.88B2023: ¥1.9B¥1.9B2024: ¥1.89B¥1.89B2025: ¥1.85B¥1.85B202122232425
R&D / revenue319.7%
2020: 130.1%130.1%2021: 91.3%91.3%2022: 135.7%135.7%2023: 117.1%117.1%2024: 296.6%296.6%2025: 319.7%319.7%202122232425

R&D is shown only for years with machine-readable disclosure. Days are estimates using year-end receivables, inventory and payables divided by annual revenue or cost of sales; financial companies are excluded.

Income statement (JPY millions)

ItemFY ending Dec 2021FY ending Dec 2022FY ending Dec 2023FY ending Dec 2024FY ending Dec 2025
Revenue2,0181,3871,626636579
Cost of revenue135172175171191
Gross profit1,8821,2151,451466388
SG&A2,4132,4852,5682,5422,463
Operating income-531-1,270-1,117-2,076-2,075
Pretax income-532-1,323-1,131-2,174-2,170
Income tax2262252
Net income attributable to owners-534-1,350-1,153-2,179-2,171
Operating margin-26.3%-91.6%-68.7%-326.3%-358.3%

Balance sheet (reported items)

Year-end figures from filings. Unreported items are omitted. Interest-bearing debt excludes lease liabilities.

Assets

Cash 42%
2%
Other assets 56%

Funding

Other liabilities 75%
Equity 25%
0%

Each bar totals 100% of assets; other is the residual.

ItemFY ending Dec 2021FY ending Dec 2022FY ending Dec 2023FY ending Dec 2024FY ending Dec 2025
Cash and equivalents¥3.82B¥3.38B¥2.89B¥2.11B¥516.8M
Total assets¥5.43B¥4.27B¥4.35B¥2.77B¥1.23B
Net assets¥4.32B¥3.64B¥3.88B¥2.48B¥309.2M
Share capital¥1.06B¥1.38B¥2.08B¥2.45B¥14.8M
Property, plant and equipment¥51.6M¥100.2M¥105.5M——
Intangible assets excluding goodwill¥2.7M¥1.9M¥1.1M——
Investment securities———¥11.4M¥28.5M
Current assets¥5.32B¥4.1B¥4.19B¥2.74B¥1.18B
Current liabilities¥774.7M¥436.4M¥375.9M¥223M¥168.1M
Long-term borrowings¥268.4M¥148.4M¥28.4M¥8.4M—
Bonds¥32M————
Total liabilities¥1.12B¥624.6M¥472.4M¥296.8M¥920.4M
Equity attributable to owners of parent¥4.29B¥3.59B¥3.83B¥2.39B¥230.7M
Retained earnings-¥1.57B-¥2.92B-¥4.08B-¥6.25B-¥1.98B
Treasury stock-¥222K-¥222K-¥222K-¥222K-¥227K

Sources

Show source documents (6)
  • EDINET (FSA Japan)

    有価証券報告書-第23期(2025/01/01-2025/12/31)

    ID S100XSFK2026-03-26Open
  • EDINET (FSA Japan)

    有価証券報告書-第22期(2024/01/01-2024/12/31)

    ID S100VEU52025-03-26Open
  • EDINET (FSA Japan)

    有価証券報告書-第21期(2023/01/01-2023/12/31)

    ID S100T2Q72024-03-27Open
  • EDINET (FSA Japan)

    有価証券報告書-第20期(2022/01/01-2022/12/31)

    ID S100QFB82023-03-27Open
  • EDINET (FSA Japan)

    有価証券報告書-第19期(令和3年1月1日-令和3年12月31日)

    ID S100NPCS2022-03-25Open
  • EDINET (FSA Japan)

    有価証券報告書-第18期(令和2年1月1日-令和2年12月31日)

    ID S100KZV22021-03-26Open

Extracted from XBRL: 40 / Derived from other figures: 1

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